Analyzing leukocyte telomere length in bipolar disorder: Authors’ reply

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Analyzing leukocyte telomere length in bipolar disorder: Authors' reply.

Our original study adds important information to the evidence base for bipolar disorder (BD) pathology. We show, for the first time, that shorter leukocyte telomere length (LTL) is already present in individuals with the early stages of BD and is comparable to LTL from individuals in the late stages of the disease. This result is at least surprising. We might speculate that, in BD, LTL would be...

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Leukocyte telomere length: the telomere tale continues.

In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...

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Aberrant leukocyte telomere length in Birdshot Uveitis

PURPOSE Birdshot Uveitis (BU) is an archetypical chronic inflammatory eye disease, with poor visual prognosis, that provides an excellent model for studying chronic inflammation. BU typically affects patients in the fifth decade of life. This suggests that it may represent an age-related chronic inflammatory disease, which has been linked to increased erosion of telomere length of leukocytes. ...

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ژورنال

عنوان ژورنال: Revista Brasileira de Psiquiatria

سال: 2017

ISSN: 1516-4446

DOI: 10.1590/1516-4446-2017-2350